Bis(indoline-2,3-diones): versatile precursors for novel bis(spirooxindoles) incorporating 4$H$-chromene-3-carbonitrile and pyrano[2,3-$d$]pyrimidine-6-carbonitrile derivatives

Authors

SAID AHMED SOLIMAN GHOZLAN
MUHAMMED ALY RAMADAN
AMR MOHMED ABDELMONIEM
AHMED H. M. ELWAHY
ISMAIL ABDELSHAFY ABDELHAMID

DOI

10.3906/kim-1609-42

Abstract

Multicomponent reaction of dimedone or 1,3-dimethylbarbituric acid and malononitrile with a series of bis(indoline-2,3-diones) afforded the corresponding bis(2-amino-7,7-dimethyl-2',5-dioxo-5,6,7,8-tetrahydrospiro[chromene-4,3'-indoline]-3-carbonitrile) and bis(7'-amino-1',3'-dimethyl-2,2',4'-trioxo-1',2',3',4'-tetrahydrospiro[indoline-3,5'-pyrano [2,3-d]pyrimidine]-6'-carbonitrile) derivatives in good to excellent yield.

Keywords

Bis(indoline-2, 3-diones), bis(spirooxindole), 4$H$-chromene-3-carbonitrile, pyrano[2, 3-$d$]pyrimidine-6-carbonitrile

First Page

410

Last Page

419

Recommended Citation

GHOZLAN, SAID AHMED SOLIMAN; RAMADAN, MUHAMMED ALY; ABDELMONIEM, AMR MOHMED; ELWAHY, AHMED H. M.; and ABDELHAMID, ISMAIL ABDELSHAFY (2017) "Bis(indoline-2,3-diones): versatile precursors for novel bis(spirooxindoles) incorporating 4$H$-chromene-3-carbonitrile and pyrano[2,3-$d$]pyrimidine-6-carbonitrile derivatives," Turkish Journal of Chemistry: Vol. 41: No. 3, Article 10. https://doi.org/10.3906/kim-1609-42
Available at: https://journals.tubitak.gov.tr/chem/vol41/iss3/10