Efficient multicomponent synthesis of 1,2,3-triazoles catalyzed by Cu(II) supported on PEI@Fe$_{3}$O$_{4}$ MNPs in a water/PEG$_{300}$ system

Authors

ZEINAB HASSANPOUR
AZIZ MALEKI
MORTEZA HOSSEINI
LENA GORGANNEZHAD
VAJIHE NEJADSHAFIEE
ALI RAMAZANI
ISMAEIL HARIRIAN
ABBAS SHAFIEE
MEHDI KHOOBI

DOI

10.3906/kim-1607-40

Abstract

A highly dispersible and magnetically recoverable Cu-PEI@Fe$_{3}$O$_{4}$ MNPs catalyst was prepared and successfully applied in one-pot three-component coupling of terminal alkynes, sodium azide, and alkyl bromides/chlorides in water to give 1,4-disubstituted 1,2,3-triazoles with good to excellent yields. The catalyst was fully characterized with FT-IR, TGA, TEM, SEM, VSM, EDX, cyclic voltammetry, and ICP-AES spectroscopic techniques. Furthermore, the catalyst was easily recycled by an external magnet and successfully reused six times in the reaction without significant loss of its catalytic activity and copper leaching. The large-scale reaction was also carried out in the absence of any base and reducing agent even with 0.1 mol% of the catalyst in aqueous media, making this protocol a good candidate for practical applications.

Keywords

Magnetic nanoparticles, copper catalyst, synthesis, 1, 2, 3-triazoles

First Page

294

Last Page

307

Recommended Citation

HASSANPOUR, ZEINAB; MALEKI, AZIZ; HOSSEINI, MORTEZA; GORGANNEZHAD, LENA; NEJADSHAFIEE, VAJIHE; RAMAZANI, ALI; HARIRIAN, ISMAEIL; SHAFIEE, ABBAS; and KHOOBI, MEHDI (2017) "Efficient multicomponent synthesis of 1,2,3-triazoles catalyzed by Cu(II) supported on PEI@Fe$_{3}$O$_{4}$ MNPs in a water/PEG$_{300}$ system," Turkish Journal of Chemistry: Vol. 41: No. 2, Article 12. https://doi.org/10.3906/kim-1607-40
Available at: https://journals.tubitak.gov.tr/chem/vol41/iss2/12