Synthesis and antifungal activity of new dihydrofurocoumarins and dihydrofuroquinolines

Authors

ASLI USTALAR
MEHMET YILMAZ
AGİM OSMANİ
SEMA AŞKIN KEÇELİ

DOI

10.3906/kim-1604-22

Abstract

We investigated the radical addition of 4-hydroxycoumarin (1a) and 4-hydroxyquinoline (1b) with conjugated dienes ({2a-f) mediated by cerium(IV) ammonium nitrate (CAN) resulting in ethenyl substituted 2,3-dihydrofurocoumarin (3a-f) and 3,5-dihydrofuroquinoline (3g, 3h) compounds in moderate to good yields. All compounds were characterized by spectroscopic methods (IR, MS, and $^{1}$H and $^{13}$C NMR) and microanalysis. Antifungal activities of these compounds were investigated against the fungi Candida albicans, C. parapsilosis, C. krusei, C. glabrata, C. tropicalis, and Aspergillus fumigatus.

Keywords

Dihydrofurocoumarin, dihydrofuroquinoline, cerium(IV) ammonium nitrate, radical cyclization

First Page

80

Last Page

88

Recommended Citation

USTALAR, ASLI; YILMAZ, MEHMET; OSMANİ, AGİM; and KEÇELİ, SEMA AŞKIN (2017) "Synthesis and antifungal activity of new dihydrofurocoumarins and dihydrofuroquinolines," Turkish Journal of Chemistry: Vol. 41: No. 1, Article 7. https://doi.org/10.3906/kim-1604-22
Available at: https://journals.tubitak.gov.tr/chem/vol41/iss1/7