Synthesis and antifungal activity of new dihydrofurocoumarins and dihydrofuroquinolines

Authors

ASLI USTALAR
MEHMET YILMAZ
AGİM OSMANİ
SEMA AŞKIN KEÇELİ

Abstract

We investigated the radical addition of 4-hydroxycoumarin (1a) and 4-hydroxyquinoline (1b) with conjugated dienes ({2a-f) mediated by cerium(IV) ammonium nitrate (CAN) resulting in ethenyl substituted 2,3-dihydrofurocoumarin (3a-f) and 3,5-dihydrofuroquinoline (3g, 3h) compounds in moderate to good yields. All compounds were characterized by spectroscopic methods (IR, MS, and $^{1}$H and $^{13}$C NMR) and microanalysis. Antifungal activities of these compounds were investigated against the fungi Candida albicans, C. parapsilosis, C. krusei, C. glabrata, C. tropicalis, and Aspergillus fumigatus.

DOI

10.3906/kim-1604-22

Keywords

Dihydrofurocoumarin, dihydrofuroquinoline, cerium(IV) ammonium nitrate, radical cyclization

First Page

80

Last Page

88

Recommended Citation

USTALAR, ASLI; YILMAZ, MEHMET; OSMANİ, AGİM; and KEÇELİ, SEMA AŞKIN (2017) "Synthesis and antifungal activity of new dihydrofurocoumarins and dihydrofuroquinolines," Turkish Journal of Chemistry: Vol. 41: No. 1, Article 7. https://doi.org/10.3906/kim-1604-22
Available at: https://journals.tubitak.gov.tr/chem/vol41/iss1/7