Graphite oxide catalyzed synthesis of $\beta $-amino alcohols by ring-opening of epoxides

Authors

MARYAM MIRZA-AGHAYAN
FARZANEH ALVANDI
MAHDIEH MOLAEE TAVANA
RABAH BOUKHERROUB

Abstract

Graphite oxide as a heterogeneous and recyclable solid acid catalyzed a simple and efficient method for the synthesis of $\beta $-amino alcohols by ring opening of epoxides with amines. This method is effective with various aromatic and aliphatic amines under solvent-free conditions. The corresponding $\beta $-amino alcohols are obtained in high yields (56%-95%) and short reaction times (15-30 min) with high regio- and chemoselectivity under metal-free conditions.

DOI

10.3906/kim-1604-45

Keywords

Ring opening, epoxides, amines, $\beta $-amino alcohols, graphite oxide, metal-free conditions

First Page

70

Last Page

79

Recommended Citation

MIRZA-AGHAYAN, MARYAM; ALVANDI, FARZANEH; TAVANA, MAHDIEH MOLAEE; and BOUKHERROUB, RABAH (2017) "Graphite oxide catalyzed synthesis of $\beta $-amino alcohols by ring-opening of epoxides," Turkish Journal of Chemistry: Vol. 41: No. 1, Article 6. https://doi.org/10.3906/kim-1604-45
Available at: https://journals.tubitak.gov.tr/chem/vol41/iss1/6