Recent advances in thymidine phosphorylase inhibitors: syntheses and prospective medicinal applications

Authors

MUHAMMAD AAMIR SAJID
ZULFIQAR ALI KHAN
SOHAIL ANJUM SHAHZAD
SYED ALİ RAZA NAQVI
MUHAMMAD USMAN
AHSAN IQBAL

DOI

10.3906/kim-1602-79

Abstract

This review paper covers recent advances in the synthetic strategies for novel TPase inhibitors and their potential medicinal applications over the last few decades. A brief introduction covering the structural aspects of TPase inhibitors is also included to facilitate understanding of diverse approaches to monitor the design of new inhibitors. TPase is an essential enzyme and its inhibition is a potential target in the development of anticancer drugs.

Keywords

Thymidine phosphorylase, platelet-derived endothelial cell growth factor (PDECGF), angiogenesis, thymidine phosphorylase inhibitors, anticancer drugs, inhibitor design

First Page

1

Last Page

28

Recommended Citation

SAJID, MUHAMMAD AAMIR; KHAN, ZULFIQAR ALI; SHAHZAD, SOHAIL ANJUM; NAQVI, SYED ALİ RAZA; USMAN, MUHAMMAD; and IQBAL, AHSAN (2017) "Recent advances in thymidine phosphorylase inhibitors: syntheses and prospective medicinal applications," Turkish Journal of Chemistry: Vol. 41: No. 1, Article 1. https://doi.org/10.3906/kim-1602-79
Available at: https://journals.tubitak.gov.tr/chem/vol41/iss1/1