The one-pot synthesis of novel 1,4-disubstituted 1,2,3-triazoles from isoquinoline-substituted homopropargyl alcohol backbone is described (42%-88% yields). A ring closing metathesis reaction and an intramolecular Pauson-Khand reaction of enyne system derived from a homopropargyl alcohol backbone to afford the corresponding isoquinoline-substituted dihydropyran and cyclopentenone-pyran, respectively, are also described (54% and 78% yields). Information about the structural, electronic, and physico-chemical properties of the novel compounds, obtained by density functional theory application, is also reported.
Isoquinoline, 1, 2, 3-triazoles, ring closing metathesis reaction, Pauson-Khand reaction
YENİDEDE, DUYGU; GÜMÜŞ, SELÇUK; and GÜMÜŞ, AYŞEGÜL
"Isoquinoline-substituted triazole and pyran derivatives: synthesis and computational studies,"
Turkish Journal of Chemistry: Vol. 40:
4, Article 11.
Available at: https://journals.tubitak.gov.tr/chem/vol40/iss4/11