Turkish Journal of Chemistry
Abstract
The one-pot synthesis of novel 1,4-disubstituted 1,2,3-triazoles from isoquinoline-substituted homopropargyl alcohol backbone is described (42%-88% yields). A ring closing metathesis reaction and an intramolecular Pauson-Khand reaction of enyne system derived from a homopropargyl alcohol backbone to afford the corresponding isoquinoline-substituted dihydropyran and cyclopentenone-pyran, respectively, are also described (54% and 78% yields). Information about the structural, electronic, and physico-chemical properties of the novel compounds, obtained by density functional theory application, is also reported.
DOI
10.3906/kim-1512-31
Keywords
Isoquinoline, 1, 2, 3-triazoles, ring closing metathesis reaction, Pauson-Khand reaction
First Page
655
Last Page
666
Recommended Citation
YENİDEDE, D, GÜMÜŞ, S, & GÜMÜŞ, A (2016). Isoquinoline-substituted triazole and pyran derivatives: synthesis and computational studies. Turkish Journal of Chemistry 40 (4): 655-666. https://doi.org/10.3906/kim-1512-31
