Isoquinoline-substituted triazole and pyran derivatives: synthesis and computational studies

Authors

DUYGU YENİDEDE
SELÇUK GÜMÜŞ
AYŞEGÜL GÜMÜŞ

DOI

10.3906/kim-1512-31

Abstract

The one-pot synthesis of novel 1,4-disubstituted 1,2,3-triazoles from isoquinoline-substituted homopropargyl alcohol backbone is described (42%-88% yields). A ring closing metathesis reaction and an intramolecular Pauson-Khand reaction of enyne system derived from a homopropargyl alcohol backbone to afford the corresponding isoquinoline-substituted dihydropyran and cyclopentenone-pyran, respectively, are also described (54% and 78% yields). Information about the structural, electronic, and physico-chemical properties of the novel compounds, obtained by density functional theory application, is also reported.

Keywords

Isoquinoline, 1, 2, 3-triazoles, ring closing metathesis reaction, Pauson-Khand reaction

First Page

655

Last Page

666

Recommended Citation

YENİDEDE, DUYGU; GÜMÜŞ, SELÇUK; and GÜMÜŞ, AYŞEGÜL (2016) "Isoquinoline-substituted triazole and pyran derivatives: synthesis and computational studies," Turkish Journal of Chemistry: Vol. 40: No. 4, Article 11. https://doi.org/10.3906/kim-1512-31
Available at: https://journals.tubitak.gov.tr/chem/vol40/iss4/11