Turkish Journal of Chemistry
Abstract
Several novel thiazolylpyrazoline derivatives were synthesized by reacting substituted 3,5-diaryl-1-thiocarba\-moyl-2-pyrazolines with phenacylbromides. The structures of the synthesized compounds were confirmed by IR, $^{1}$H NMR, $^{13}$C NMR, and MS spectral data. Their antimicrobial activities against Staphylococcus aureus(ATCC-25923), Enterococcus faecalis} (ATCC-29212), Enterococcus faecalis (ATCC-51922), Listeria monocytogenes (ATCC-1911), Klebsiella pneumoniae (ATCC-700603), Pseudomonas aeruginosa (ATCC-27853), Escherichia coli (ATCC-35218), Escherichia coli (ATCC-25922), Candida albicans (ATCC-90028), Candida glabrata (ATCC-90030), Candida krusei (ATCC-6258), and Candida parapsilosis (ATCC-22019) were investigated. The compounds were also studied for their cytotoxic effects using a MTT assay. Compound 7c showed the highest antimicrobial activity, possessing the same potential as chloramphenicol against K. pneumonia, P. aeruginosa, and E. coli (ATCC-25923).
DOI
10.3906/kim-1512-12
Keywords
2-Pyrazoline, thiazole, thiazolylpyrazoline, antimicrobial activity, cytotoxicity
First Page
641
Last Page
654
Recommended Citation
TABBI, A, KAPLANCIKLI, Z. A, TEBBANI, D, YURTTAŞ, L, CANTÜRK, Z, ATLI, Ö, BAYSAL, M, & ZITOUNI, G. T (2016). Synthesis of novel thiazolylpyrazoline derivatives and evaluation of their antimicrobial activities and cytotoxicities. Turkish Journal of Chemistry 40 (4): 641-654. https://doi.org/10.3906/kim-1512-12
