Synthesis of novel thiazolylpyrazoline derivatives and evaluation of their antimicrobial activities and cytotoxicities

Authors

AOUATEF TABBI
ZAFER ASIM KAPLANCIKLI
DAHMANE TEBBANI
LEYLA YURTTAŞ
ZERRİN CANTÜRK
ÖZLEM ATLI
MERVE BAYSAL
GÜLHAN TURAN ZITOUNI

DOI

10.3906/kim-1512-12

Abstract

Several novel thiazolylpyrazoline derivatives were synthesized by reacting substituted 3,5-diaryl-1-thiocarba\-moyl-2-pyrazolines with phenacylbromides. The structures of the synthesized compounds were confirmed by IR, $^{1}$H NMR, $^{13}$C NMR, and MS spectral data. Their antimicrobial activities against Staphylococcus aureus(ATCC-25923), Enterococcus faecalis} (ATCC-29212), Enterococcus faecalis (ATCC-51922), Listeria monocytogenes (ATCC-1911), Klebsiella pneumoniae (ATCC-700603), Pseudomonas aeruginosa (ATCC-27853), Escherichia coli (ATCC-35218), Escherichia coli (ATCC-25922), Candida albicans (ATCC-90028), Candida glabrata (ATCC-90030), Candida krusei (ATCC-6258), and Candida parapsilosis (ATCC-22019) were investigated. The compounds were also studied for their cytotoxic effects using a MTT assay. Compound 7c showed the highest antimicrobial activity, possessing the same potential as chloramphenicol against K. pneumonia, P. aeruginosa, and E. coli (ATCC-25923).

Keywords

2-Pyrazoline, thiazole, thiazolylpyrazoline, antimicrobial activity, cytotoxicity

First Page

641

Last Page

654

Recommended Citation

TABBI, AOUATEF; KAPLANCIKLI, ZAFER ASIM; TEBBANI, DAHMANE; YURTTAŞ, LEYLA; CANTÜRK, ZERRİN; ATLI, ÖZLEM; BAYSAL, MERVE; and ZITOUNI, GÜLHAN TURAN (2016) "Synthesis of novel thiazolylpyrazoline derivatives and evaluation of their antimicrobial activities and cytotoxicities," Turkish Journal of Chemistry: Vol. 40: No. 4, Article 10. https://doi.org/10.3906/kim-1512-12
Available at: https://journals.tubitak.gov.tr/chem/vol40/iss4/10