Synthesis and evaluation of some novel thiazoles and 1,3-thiazines as potent agents against the rabies virus

Authors

MAGDA ABDALLA
SOBHI GOMHA
MOHAMAD ABD ELAZIZ
NANY SERAG

DOI

10.3906/kim-1506-13

Abstract

A series of novel thiazoles and 1,3-thiazine derivatives were synthesized in good yield via reaction of ethyl 3-(1-(2-thiocarbamoylhydrazono)ethyl)-1,5-diphenyl-1$H$-pyrazole-4-carboxylate with hydrazonoyl halides and arylidenemalononitriles, respectively. The structure of the newly synthesized products was elucidated via elemental analysis, spectral data, and alternative routes whenever possible. Moreover, the antiviral screening of the products was evaluated and the results revealed that some of them have strong to moderate potency against the rabies virus compared with the reference drug.

Keywords

Thiazoles, 1, 3-thiazines, thiosemicarbazone, hydrazonoyl halides, antiviral evaluation

First Page

441

Last Page

453

Recommended Citation

ABDALLA, MAGDA; GOMHA, SOBHI; ELAZIZ, MOHAMAD ABD; and SERAG, NANY (2016) "Synthesis and evaluation of some novel thiazoles and 1,3-thiazines as potent agents against the rabies virus," Turkish Journal of Chemistry: Vol. 40: No. 3, Article 8. https://doi.org/10.3906/kim-1506-13
Available at: https://journals.tubitak.gov.tr/chem/vol40/iss3/8