New antimicrobial biscembrane hydrocarbon and cembranoid diterpenes from the soft coral Sarcophyton trocheliophorum

Authors

MUHAMMAD ZUBAIR
WALIED ALARIF
KHALID AL-FOOTY
MOHAMED PH
MAGDA ALI
SALIM BASAIF
SULTAN AL-LIHAIBI
SEIF-ELDIN AYYAD

DOI

10.3906/kim-1502-82

Abstract

A new tetracyclic biscembrane hydrocarbon, trocheliane (1), along with two new cembranoid diterpenes, sarcotrocheldiol A (2) and B (3), and the known diterpene cembrene-C (4), were isolated from the Red Sea soft coral Sarcophyton trocheliophorum. The structures and relative stereochemistry of the compounds were elucidated by interpretation of MS, 1 D NMR, and 2 D NMR experiments. The sensitivity of some pathogenic bacteria used as test organisms to the new compounds 1-3 was determined. 1 showed appreciable antimicrobial activity with the diameter of inhibition zones ranging from 11 to 18 mm. 1 was active against the two multidrug resistant bacteria Acinetobacter baumannii and Staphylococcus aureus. Minimal inhibitory concentrations (MICs) of compound 1 were recorded for all the tested bacteria using the fluorescein diacetate method and the recorded MIC values ranged from 4 to 6 $\mu $M.

Keywords

Soft coral, biscembranes, diterpenoids, antibacterial activity

First Page

385

Last Page

392

Recommended Citation

ZUBAIR, MUHAMMAD; ALARIF, WALIED; AL-FOOTY, KHALID; PH, MOHAMED; ALI, MAGDA; BASAIF, SALIM; AL-LIHAIBI, SULTAN; and AYYAD, SEIF-ELDIN (2016) "New antimicrobial biscembrane hydrocarbon and cembranoid diterpenes from the soft coral Sarcophyton trocheliophorum," Turkish Journal of Chemistry: Vol. 40: No. 3, Article 2. https://doi.org/10.3906/kim-1502-82
Available at: https://journals.tubitak.gov.tr/chem/vol40/iss3/2