Synthetic access to some new benzothiazole-based 1,3,4-thiadiazole and 1,3-thiazole derivatives

Authors

KAMAL M. DAWOOD
EMAN A. RAGAB
KORANY A. ALI

DOI

10.3906/kim-1503-75

Abstract

1-(Benzothiazol-2-yl)-3-phenylthiourea\textbf{ 2} was prepared and treated with hydrazonoyl chlorides \textbf{3a}--\textbf{e }to yield the corresponding 5-(benzothiazol-2-ylimino)-1,3,4-thiadiazole derivatives \textbf{6a}--\textbf{e}, respectively. Reaction of the thiourea derivative \textbf{2} with ethyl 2-chloro-3-oxobutanoate \textbf{9} afforded the corresponding 2-(benzothiazol-2-ylimino)thiazole-5-carboxylate derivative \textbf{11}. The newly synthesized heterocyclic derivatives were confirmed from their elemental and spectral analyses.

Keywords

Benzothiazole, thiazole, thiadiazole, thiourea, hydrazonoyl chlorides

First Page

277

Last Page

282

Recommended Citation

DAWOOD, KAMAL M.; RAGAB, EMAN A.; and ALI, KORANY A. (2016) "Synthetic access to some new benzothiazole-based 1,3,4-thiadiazole and 1,3-thiazole derivatives," Turkish Journal of Chemistry: Vol. 40: No. 2, Article 5. https://doi.org/10.3906/kim-1503-75
Available at: https://journals.tubitak.gov.tr/chem/vol40/iss2/5