Synthetic access to some new benzothiazole-based 1,3,4-thiadiazole and 1,3-thiazole derivatives

Authors

KAMAL M. DAWOOD
EMAN A. RAGAB
KORANY A. ALI

Abstract

1-(Benzothiazol-2-yl)-3-phenylthiourea\textbf{ 2} was prepared and treated with hydrazonoyl chlorides \textbf{3a}--\textbf{e }to yield the corresponding 5-(benzothiazol-2-ylimino)-1,3,4-thiadiazole derivatives \textbf{6a}--\textbf{e}, respectively. Reaction of the thiourea derivative \textbf{2} with ethyl 2-chloro-3-oxobutanoate \textbf{9} afforded the corresponding 2-(benzothiazol-2-ylimino)thiazole-5-carboxylate derivative \textbf{11}. The newly synthesized heterocyclic derivatives were confirmed from their elemental and spectral analyses.

DOI

10.3906/kim-1503-75

Keywords

Benzothiazole, thiazole, thiadiazole, thiourea, hydrazonoyl chlorides

First Page

277

Last Page

282

Recommended Citation

DAWOOD, KAMAL M.; RAGAB, EMAN A.; and ALI, KORANY A. (2016) "Synthetic access to some new benzothiazole-based 1,3,4-thiadiazole and 1,3-thiazole derivatives," Turkish Journal of Chemistry: Vol. 40: No. 2, Article 5. https://doi.org/10.3906/kim-1503-75
Available at: https://journals.tubitak.gov.tr/chem/vol40/iss2/5