Synthesis of novel chiral bisoxazoline ligands with a norbornadiene backbone: use in the copper-catalyzed enantioselective Henry reaction

Authors

RABİA DELİKUŞ
EMİNE ÇAKIR
NADİR DEMİREL
METİN BALCI
BETÜL KARATAŞ

DOI

10.3906/kim-1504-80

Abstract

Novel chiral bisoxazoline ligands based on norbornadiene were synthesized and used for the asymmetric Henry reaction. Various aromatic aldehydes were converted into chiral $\beta $-nitro alcohols with high yields and moderate to acceptable enantioselectivities under the optimized reaction conditions.

Keywords

Asymmetric synthesis, Henry reaction, chiral bisoxazolines, nitroaldol, copper

First Page

248

Last Page

261

Recommended Citation

DELİKUŞ, RABİA; ÇAKIR, EMİNE; DEMİREL, NADİR; BALCI, METİN; and KARATAŞ, BETÜL (2016) "Synthesis of novel chiral bisoxazoline ligands with a norbornadiene backbone: use in the copper-catalyzed enantioselective Henry reaction," Turkish Journal of Chemistry: Vol. 40: No. 2, Article 3. https://doi.org/10.3906/kim-1504-80
Available at: https://journals.tubitak.gov.tr/chem/vol40/iss2/3