Synthetic approaches towards the synthesis of beta-blockers (betaxolol, metoprolol, sotalol, and timolol)

Authors

FURQAN AHMAD SADDIQUE
AMEER FAWAD ZAHOOR
MUHAMMMAD YOUSAF
MUHAMMMAD IRFAN
MATLOOB AHMAD
ASIM MANSHA
ZULFIQAR ALI KHAN
SYED ALI RAZA NAQVI

Abstract

Numerous efficient synthetic methodologies have been elaborated for the synthesis of $\beta $-blockers since the introduction of propranolol (a beta-blocker) in 1968. In this review, focus is placed on the more concise asymmetric and bioenzymatic synthetic approaches attempted towards the synthesis of beta-blockers (betaxolol, metoprolol, sotalol, and timolol).

DOI

10.3906/kim-1504-65

Keywords

Beta-blockers, cardiovascular activity, antiglaucoma agent, biotransformations

First Page

193

Last Page

224

Recommended Citation

SADDIQUE, F. A, ZAHOOR, A. F, YOUSAF, M, IRFAN, M, AHMAD, M, MANSHA, A, KHAN, Z. A, & NAQVI, S. A (2016). Synthetic approaches towards the synthesis of beta-blockers (betaxolol, metoprolol, sotalol, and timolol). Turkish Journal of Chemistry 40 (2): 193-224. https://doi.org/10.3906/kim-1504-65