Synthetic approaches towards the synthesis of beta-blockers (betaxolol, metoprolol, sotalol, and timolol)

Authors

FURQAN AHMAD SADDIQUE
AMEER FAWAD ZAHOOR
MUHAMMMAD YOUSAF
MUHAMMMAD IRFAN
MATLOOB AHMAD
ASIM MANSHA
ZULFIQAR ALI KHAN
SYED ALI RAZA NAQVI

DOI

10.3906/kim-1504-65

Abstract

Numerous efficient synthetic methodologies have been elaborated for the synthesis of $\beta $-blockers since the introduction of propranolol (a beta-blocker) in 1968. In this review, focus is placed on the more concise asymmetric and bioenzymatic synthetic approaches attempted towards the synthesis of beta-blockers (betaxolol, metoprolol, sotalol, and timolol).

Keywords

Beta-blockers, cardiovascular activity, antiglaucoma agent, biotransformations

First Page

193

Last Page

224

Recommended Citation

SADDIQUE, FURQAN AHMAD; ZAHOOR, AMEER FAWAD; YOUSAF, MUHAMMMAD; IRFAN, MUHAMMMAD; AHMAD, MATLOOB; MANSHA, ASIM; KHAN, ZULFIQAR ALI; and NAQVI, SYED ALI RAZA (2016) "Synthetic approaches towards the synthesis of beta-blockers (betaxolol, metoprolol, sotalol, and timolol)," Turkish Journal of Chemistry: Vol. 40: No. 2, Article 1. https://doi.org/10.3906/kim-1504-65
Available at: https://journals.tubitak.gov.tr/chem/vol40/iss2/1