Palladium-catalyzed ligand-free and efficient Suzuki--Miyaura reaction of $N$-methyliminodiacetic acid boronates in water

Authors

CHUN LIU
XINMIN LI
XINNAN WANG
JIESHAN QIU

DOI

10.3906/kim-1505-97

Abstract

A green and efficient protocol has been developed for the Pd(OAc)$_{2}$-catalyzed ligand-free Suzuki--Miyaura reaction of $N$-methyliminodiacetic acid (MIDA) boronates in water. In the presence of Pd(OAc)$_{2}$ as a catalyst and ($i$-Pr)$_{2}$NH as a base, the cross-coupling reactions of aryl bromides with aryl MIDA boronates proceeded smoothly in water without any surfactant, and various functional groups were tolerated under the optimized conditions.

Keywords

Palladium, ligand-free, Suzuki--Miyaura reaction, $N$-methyliminodiacetic acid boronates, water

First Page

1208

Last Page

1215

Recommended Citation

LIU, CHUN; LI, XINMIN; WANG, XINNAN; and QIU, JIESHAN (2015) "Palladium-catalyzed ligand-free and efficient Suzuki--Miyaura reaction of $N$-methyliminodiacetic acid boronates in water," Turkish Journal of Chemistry: Vol. 39: No. 6, Article 7. https://doi.org/10.3906/kim-1505-97
Available at: https://journals.tubitak.gov.tr/chem/vol39/iss6/7