A simple approach to bis-spirocycles and spiroindole derivatives via green methods such as Fischer indolization, ring-closing metathesis, and Suzuki--Miyaura cross-coupling

Authors

SAMBASIVARAO KOTHA
RASHID ALI

DOI

10.3906/kim-1502-116

Abstract

We have developed a simple synthetic methodology for bis-spirocycles and spiroindole derivatives starting with a commercially available 6-bromo-2-tetralone. Here, we have used Fischer indolization, ring-closing metathesis, and Suzuki--Miyaura cross-coupling as key steps to assemble a variety of spirocyclic frameworks. The methodology developed here is simple and it may be useful to prepare various spirocycles containing indole moiety.

Keywords

Spirocycles, Fischer indolization, ring-closing metathesis, Suzuki coupling, Grubbs' catalyst

First Page

1190

Last Page

1198

Recommended Citation

KOTHA, SAMBASIVARAO and ALI, RASHID (2015) "A simple approach to bis-spirocycles and spiroindole derivatives via green methods such as Fischer indolization, ring-closing metathesis, and Suzuki--Miyaura cross-coupling," Turkish Journal of Chemistry: Vol. 39: No. 6, Article 5. https://doi.org/10.3906/kim-1502-116
Available at: https://journals.tubitak.gov.tr/chem/vol39/iss6/5