•  
  •  
 

Turkish Journal of Chemistry

DOI

10.3906/kim-1504-13

Abstract

A new series of 7-arylazo-5$H$-3-(trifluoromethyl)-6-methyl-1,2,4-triazolo-[3,4-$b$]-1,3,4-thiadiazines was prepared by reaction of 4-amino-3-trifluoromethyl-5-mercapto-1,2,4-triazoles with $N$-aryl-2-oxo-propane hydrazonoyl chloride in dioxane under reflux in the presence of triethylamine. Furthermore, Schiff bases of 4-amino-5-mercapto-1,2,4-triazole derivatives were reacted with a variety of hydrazonoyl chlorides and gave the respective hydrazonothioates. In addition, the novel \textit{bis}-(1,2,4-triazole-3-thione) was reacted with the appropriate hydrazonoyl chloride in dioxane under reflux in the presence of triethylamine to give the corresponding \textit{bis}-(1,2,4-triazolethiohydrazonoate). The structures of the new compounds were established based on elemental and spectral data. The mechanism of the studied reaction was also discussed. Moreover, some of the new products were screened for their anticancer activity and the results obtained are promising and indicate that compounds \textbf{4a }and \textbf{4i} are the most active inhibitors against HEPG-2 and compounds \textbf{4a} and \textbf{13b} are active against HCT cell lines.

Keywords

4-Amino-3-trifluoromethyl-5-mercapto-1, 2, 4-triazole, hydrazonoyl halides, anticancer activity, triazolo[3, 4-$b$][1, 3, 4]thiadiazines

First Page

955

Last Page

969

Download

Included in

Chemistry Commons

Share

COinS