Microwave-assisted synthesis of novel 8-chloro-[1,2,4]triazolo[4,3-$a$]pyridine derivatives

Authors

LINJIONG ZHANG
MINGYAN YANG
BEIZHEN HU
ZHAOHUI SUN
XINGHAI LIU
JIANQUAN WENG
CHENGXIA TAN

DOI

10.3906/kim-1408-78

Abstract

A series of novel 1,2,4-triazolo[4,3-$a$]pyridine derivatives were synthesized from 2,3-dichloropyridine and hydrazine hydrate as starting materials by multistep reactions under microwave assistance, and their structures were characterized by $^{1}$H NMR, MS, and elemental analysis. This method provides several advantages such as high yields, facile work-up, and environmental friendliness.

Keywords

1, 2, 4-Triazolo[4, 3-$a$]pyridine, urea, microwave-assisted synthesis

First Page

867

Last Page

873

Recommended Citation

ZHANG, LINJIONG; YANG, MINGYAN; HU, BEIZHEN; SUN, ZHAOHUI; LIU, XINGHAI; WENG, JIANQUAN; and TAN, CHENGXIA (2015) "Microwave-assisted synthesis of novel 8-chloro-[1,2,4]triazolo[4,3-$a$]pyridine derivatives," Turkish Journal of Chemistry: Vol. 39: No. 4, Article 14. https://doi.org/10.3906/kim-1408-78
Available at: https://journals.tubitak.gov.tr/chem/vol39/iss4/14