Regiospecific one-pot, combinatorial synthesis of new substituted pyrimido[4,5-c]pyridazines as potential monoamine oxidase inhibitors

Authors

MEHDI RIMAZ
PARIA POURHOSSEIN
BEHZAD KHALILI

DOI

10.3906/kim-1408-32

Abstract

New 3-aryl-6-methylpyrimido[4,5-c]pyridazine-5,7(6H,8H)-diones and 3-aryl-6-ethyl-7-thioxo-7,8-dihydropyrimido[4,5-c]pyridazin-5(6H)-ones were efficiently synthesized via a regiospecific one-pot reaction of N-methylbarbituric acid and N-ethyl-2-thiobarbituric acid with various arylglyoxal monohydrates in the presence of hydrazine dihydrochloride in ethanol at 50 °C. The target compounds were obtained in high yields and were regioisomerically pure after recrystallization. These new heterocycles may act as potential MAO_{B} inhibitors.

Keywords

Pyrimido[4, 5-c]pyridazine, regiospecific, arylglyoxal, N-methylbarbituric acid, N-ethyl-2-thiobarbituric acid

First Page

244

Last Page

254

Recommended Citation

RIMAZ, MEHDI; POURHOSSEIN, PARIA; and KHALILI, BEHZAD (2015) "Regiospecific one-pot, combinatorial synthesis of new substituted pyrimido[4,5-c]pyridazines as potential monoamine oxidase inhibitors," Turkish Journal of Chemistry: Vol. 39: No. 2, Article 4. https://doi.org/10.3906/kim-1408-32
Available at: https://journals.tubitak.gov.tr/chem/vol39/iss2/4