Diphenylethoxy-substituted metal-free and metallophthalocyanines as potential photosensitizer for photodynamic therapy: synthesis and photophysical and photochemical properties

Authors

YUSUF YILMAZ
ALİ ERDOĞMUŞ
MUHAMMET KASIM ŞENER

DOI

10.3906/kim-1406-29

Abstract

The synthesis of a 4-(2,2-diphenylethoxy)phthalonitrile (1) and its organosoluble free base (2), zinc(II) (3), nickel(II) (4), and cobalt(II) (5) phthalocyanine derivatives is presented in this work. The novel complexes were characterized by elemental analyses and spectral data such as infrared, nuclear magnetic resonance, ultraviolet visible, and mass data. General tendencies were described for photophysics (fluorescence) and photochemistry (photodegradation and singlet oxygen quantum yields) of the free base and zinc(II) phthalocyanine derivatives in dimethylformamide. The quantum yield values of fluorescence (\Phi_F), singlet oxygen formation (\Phi_{\Delta}), and photodegradation (\Phi_d) for the zinc phthalocyanine were found to be 0.37, 0.48, and 9.12 \times 10^{-4}, respectively. The photophysicochemical properties of the phthalocyanines (2 and 3) clearly reveal that these phthalocyanines could be used in singlet oxygen applications such as photodynamic therapy.

Keywords

Phthalocyanine, singlet oxygen, photodynamic therapy, fluorescence quantum yield

First Page

1083

Last Page

1093

Recommended Citation

YILMAZ, YUSUF; ERDOĞMUŞ, ALİ; and ŞENER, MUHAMMET KASIM (2014) "Diphenylethoxy-substituted metal-free and metallophthalocyanines as potential photosensitizer for photodynamic therapy: synthesis and photophysical and photochemical properties," Turkish Journal of Chemistry: Vol. 38: No. 6, Article 13. https://doi.org/10.3906/kim-1406-29
Available at: https://journals.tubitak.gov.tr/chem/vol38/iss6/13