Calixcephems: clustered cephalosporins analogous to calixpenams as novel potential anti-MRSA agents

Authors

FAZEL NASUHI PUR
KARIM AKBARI DILMAGHANI

DOI

10.3906/kim-1403-2

Abstract

Two novel clusters of cephalosporin based on calixarene were synthesized directly or by ring expansion of the penicillin arms of calixpenams to the corresponding cephem arms via sulfoxide intermediates. Antibiotic tests showed that calixcephems have a noteworthy increase in antibacterial activity against methicillin-resistant strains of Staphylococcus aureus (MRSA) with respect to parent calixpenams and their corresponding single cephems.

Keywords

Calixcephem, calixpenam, calixarene, cluster, Staphylococcus aureus

First Page

850

Last Page

858

Recommended Citation

PUR, FAZEL NASUHI and DILMAGHANI, KARIM AKBARI (2014) "Calixcephems: clustered cephalosporins analogous to calixpenams as novel potential anti-MRSA agents," Turkish Journal of Chemistry: Vol. 38: No. 5, Article 16. https://doi.org/10.3906/kim-1403-2
Available at: https://journals.tubitak.gov.tr/chem/vol38/iss5/16