Turkish Journal of Chemistry
Abstract
Some thiazole derivatives bearing dithiocarbamic acid esters were synthesized in order to investigate their anticandidal activity and cytotoxicity. The structures of the obtained final compounds (6a--j) were confirmed by spectral data (IR, ^1H NMR, ^{13}C NMR, and MS) and elemental analysis. The anticandidal activity of the compounds was determined (6a--j) using the microbroth dilution method and their cytotoxicity was evaluated according to the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay against normal cells. Contrary to expectations, weak antifungal activity was observed with IC_{50} values ranging between 30 and 403 \mu g/mL.
DOI
10.3906/kim-1312-62
Keywords
Thiazole, dithiocarbamate, anticandidal activity, cytotoxicity
First Page
815
Last Page
824
Recommended Citation
YURTTAŞ, LEYLA; ÖZKAY, YUSUF; DEMİRCİ, FATİH; GÖGER, GAMZE; YILDIRIM, ŞAFAK ULUSOYLAR; MOHSEN, USAMA ABU; ÖZTÜRK, ÖMER; and KAPLANCIKLI, ZAFER ASIM
(2014)
"Synthesis, anticandidal activity, and cytotoxicity of some thiazole derivatives with dithiocarbamate side chains,"
Turkish Journal of Chemistry: Vol. 38:
No.
5, Article 13.
https://doi.org/10.3906/kim-1312-62
Available at:
https://journals.tubitak.gov.tr/chem/vol38/iss5/13