The Heck coupling of haloarenes with various alkenes was successfully performed in the presence of 0.25 mol % PdCl_2 and 0.5 mol % biphenyl-4-yl-[4(5)-(biphenyl-4-yl)-1H-imidazol-2-yl]ketone 2f as a ligand with Na_2CO_3 as optimal base, in a 1:1 mixture of H_2O/DMF as the reaction solvent at 80 ^°C for 8 h. Imidazole 2f was found to be an inexpensive, air-stable, easily available, and efficient ligand in the palladium-catalyzed Heck reactions of aryl iodides (76 %--94 %), bromides (52 %--79 %), and chlorides (40 %--70 %).
AMINI, MOJTABA; AMINI, SEYEDEH MOTAHHAREH; EFTEKHARI-SIS, BAGHER; and KEIVANLOO, ALI
"Application of 3-aroyl-4(5)-arylimidazols as efficient ligands in Pd-catalyzed Heck reactions,"
Turkish Journal of Chemistry: Vol. 38:
4, Article 4.
Available at: https://journals.tubitak.gov.tr/chem/vol38/iss4/4