Spectroscopic investigation and oxidation of the anticholinergic drug atropine sulfate monohydrate by hexacyanoferrate(III) in aqueous alkaline media: a mechanistic approach

Authors

MANJUNATH METI
SHARANAPPA NANDIBEWOOR
SHIVAMURTI CHIMATADAR

DOI

10.3906/kim-1307-4

Abstract

The oxidation of the anticholinergic drug atropine sulfate monohydrate by hexacyanoferrate(III) in aqueous alkaline media was investigated spectrophotometrically by monitoring the decrease in absorbance of hexacyanoferrate(III) (HCF(III)). Oxidation products were identified. The oxidation mechanism was proposed from kinetic studies. The reaction constants involved in the different steps of the mechanism were calculated. The effects of added products, ionic strength, and dielectric constant of the reaction were investigated. The polymerization test revealed that oxidation occurred with intervention of free radicals. The activation parameters were evaluated.

Keywords

Kinetics of oxidation, mechanism, hexacyanoferrate(III), atropine sulfate

First Page

477

Last Page

487

Recommended Citation

METI, MANJUNATH; NANDIBEWOOR, SHARANAPPA; and CHIMATADAR, SHIVAMURTI (2014) "Spectroscopic investigation and oxidation of the anticholinergic drug atropine sulfate monohydrate by hexacyanoferrate(III) in aqueous alkaline media: a mechanistic approach," Turkish Journal of Chemistry: Vol. 38: No. 3, Article 13. https://doi.org/10.3906/kim-1307-4
Available at: https://journals.tubitak.gov.tr/chem/vol38/iss3/13