Study of the interaction between glucosamine hydrochloride and sodium dodecylsulphate micelles using conductometric, isothermal calorimetry, zeta-potential titrations, and NMR NOESY

Authors

MARCOS ROBERTO ABREU ALVES
LUCIANO SINDRA VIRTUOSO
ELSON SANTIAGO DE ALVARENGA
ÂNGELO MÁRCIO LEITE DENADAI

Abstract

The aim of this work was to investigate the influence of an anti-inflammatory agent, the bulky counterion named glucosamine (Gl^+), in sodium dodecylsulphate (SDS) in 2 ways: 1) by titration of SDS solutions with different concentrations of Gl^+; and 2) by titration of Gl^+ with SDS solution with concentration close to the critical micellar concentration (cmc) (7.7 mM). In procedure 1, micellisation study by isothermal titration calorimetry (ITC) showed that the increase in Gl^+ concentration reduces the cmc and the micellisation enthalpy. Increasing of the micellisation entropy was also observed, suggesting desolvation of micellar structures as a consequence of electrostatic attraction with Gl^+ ions. In procedure 2, titration of Gl^+ with SDS solution at 7.7 mM showed the existence of 3 distinct ranges of glucosamine/SDS concentrations, which were attributed to I) Gl^+ inducing micellisation, II) neutralisation of the micelles, and III) competition between the ions themselves in the micellar surface.

DOI

10.3906/kim-1306-22

Keywords

SDS, micelles, glucosamine hydrochloride, osteoarthritis

First Page

248

Last Page

259

Recommended Citation

ALVES, MARCOS ROBERTO ABREU; VIRTUOSO, LUCIANO SINDRA; ALVARENGA, ELSON SANTIAGO DE; and DENADAI, ÂNGELO MÁRCIO LEITE (2014) "Study of the interaction between glucosamine hydrochloride and sodium dodecylsulphate micelles using conductometric, isothermal calorimetry, zeta-potential titrations, and NMR NOESY," Turkish Journal of Chemistry: Vol. 38: No. 2, Article 8. https://doi.org/10.3906/kim-1306-22
Available at: https://journals.tubitak.gov.tr/chem/vol38/iss2/8