Aryl butenoic acid derivatives as a new class of histone deacetylase inhibitors: synthesis, in vitro evaluation, and molecular docking studies

Authors

PERUZE AYHAN EŞİYOK
ÖZLEM SEVEN
GÜLÜZAR EYMUR
GAMZE BORA TATAR
DİDEM DAYANGAÇ ERDEN
KEMAL YELEKÇİ
HAYAT YURTER
AYHAN SITKI DEMİR

DOI

10.3906/kim-1305-56

Abstract

New aryl butenoic acid derivatives have been synthesized by combining hydroxy- or methoxy-substituted phenyl rings as the capping group, with a double bond in the short linker as well as metal binding groups, enoic ester, and salts bearing either methyl or morpholine. These compounds have been shown to possess promising histone deacetylase inhibition activities via in vitro fluorometric assay and molecular docking studies.

Keywords

Histone deacetylase inhibition activity, aryl butenoic acid derivatives, molecular docking

First Page

338

Last Page

344

Recommended Citation

EŞİYOK, PERUZE AYHAN; SEVEN, ÖZLEM; EYMUR, GÜLÜZAR; TATAR, GAMZE BORA; ERDEN, DİDEM DAYANGAÇ; YELEKÇİ, KEMAL; YURTER, HAYAT; and DEMİR, AYHAN SITKI (2014) "Aryl butenoic acid derivatives as a new class of histone deacetylase inhibitors: synthesis, in vitro evaluation, and molecular docking studies," Turkish Journal of Chemistry: Vol. 38: No. 2, Article 16. https://doi.org/10.3906/kim-1305-56
Available at: https://journals.tubitak.gov.tr/chem/vol38/iss2/16