Calixpenams: synthesis, characterization, and biological evaluation of penicillins V and X clustered by calixarene scaffold

Authors

FAZEL NASUHI PUR
KARIM AKBARI DILMAGHANI

DOI

10.3906/kim-1307-32

Abstract

Four 6-aminopenicillanic acid moieties were grafted at either rim of calix[4]arene, giving 2 novel generations of penicillin, which were named calixpenam. Antibiotic tests showed that they have amplified activity with respect to the corresponding penams against 3 gram-positive nonpenicillinase-producing strains of Streptococcus.

Keywords

Calixpenam, Calixarene, 6-aminopenicillanic acid, nonpenicillinase, Streptococcus strains

First Page

288

Last Page

296

Recommended Citation

PUR, FAZEL NASUHI and DILMAGHANI, KARIM AKBARI (2014) "Calixpenams: synthesis, characterization, and biological evaluation of penicillins V and X clustered by calixarene scaffold," Turkish Journal of Chemistry: Vol. 38: No. 2, Article 11. https://doi.org/10.3906/kim-1307-32
Available at: https://journals.tubitak.gov.tr/chem/vol38/iss2/11