Synthesis and antimicrobial activity of novel 2-[4-(1H-benzimidazol-1-yl)phenyl]-1H-benzimidazoles

Authors

MEHMET ALP
ALİ HAKAN GÖKER
NURTEN ALTANLAR

DOI

10.3906/kim-1303-81

Abstract

A new class of 2-[4-(1H-benzimidazol-1-yl)phenyl]-1H-benzimidazoles (13--22) were synthesized via cyclocondensation reaction of the substituted 1,2-phenylenediamines (1, 4--12) and 1-(4-formylpheny)-1H-benzimidazole (3). The synthesized compounds were evaluated for antibacterial and antifungal activities against S. aureus, methicillin-resistant Staphylococcus aureus (MRSA), and Candida albicans by the tube dilution method. Compounds 13, 15, 18, 20, and 21 have moderate antifungal activity against C. albicans.

Keywords

1H-Benzimidazole, antimicrobial activities, methicillin resistant Staphylococcus aureus, Candida albicans

First Page

152

Last Page

156

Recommended Citation

ALP, MEHMET; GÖKER, ALİ HAKAN; and ALTANLAR, NURTEN (2014) "Synthesis and antimicrobial activity of novel 2-[4-(1H-benzimidazol-1-yl)phenyl]-1H-benzimidazoles," Turkish Journal of Chemistry: Vol. 38: No. 1, Article 15. https://doi.org/10.3906/kim-1303-81
Available at: https://journals.tubitak.gov.tr/chem/vol38/iss1/15