Synthesis and antimicrobial activity of novel 2-[4-(1H-benzimidazol-1-yl)phenyl]-1H-benzimidazoles

Authors

MEHMET ALP
ALİ HAKAN GÖKER
NURTEN ALTANLAR

Abstract

A new class of 2-[4-(1H-benzimidazol-1-yl)phenyl]-1H-benzimidazoles (13--22) were synthesized via cyclocondensation reaction of the substituted 1,2-phenylenediamines (1, 4--12) and 1-(4-formylpheny)-1H-benzimidazole (3). The synthesized compounds were evaluated for antibacterial and antifungal activities against S. aureus, methicillin-resistant Staphylococcus aureus (MRSA), and Candida albicans by the tube dilution method. Compounds 13, 15, 18, 20, and 21 have moderate antifungal activity against C. albicans.

DOI

10.3906/kim-1303-81

Keywords

1H-Benzimidazole, antimicrobial activities, methicillin resistant Staphylococcus aureus, Candida albicans

First Page

152

Last Page

156

Recommended Citation

ALP, M, GÖKER, A. H, & ALTANLAR, N (2014). Synthesis and antimicrobial activity of novel 2-[4-(1H-benzimidazol-1-yl)phenyl]-1H-benzimidazoles. Turkish Journal of Chemistry 38 (1): 152-156. https://doi.org/10.3906/kim-1303-81