Simple and convenient preparation of novel 6,8-disubstituted quinoline derivatives and their promising anticancer activities

Authors

SALİH ÖKTEN
OSMAN ÇAKMAK
RAMAZAN ERENLER
ÖNEM YÜCE ŞAHİN
ŞABAN TEKİN

DOI

10.3906/kim-1301-30

Abstract

A short and easy route is described for 6,8-disubstituted derivatives of quinoline and 1,2,3,4-tetrahydroquinoli- ne from 6,8-dibromoquinolines 2 and 7 by various substitution reactions. While copper-promoted substitution of 6,8-dibromide 2 produced monomethoxides 3 and 4, a prolonged reaction time mainly afforded dimethoxide 6 instead of 5, whose aromatization with DDQ and substitution reaction of dibromide 7 with NaOMe in the presence of CuI also gave rise to dimethoxide 6. Several 6,8-disubstituted quinolines were obtained by treatment of 6,8-dibromoquinoline (7) with n-BuLi followed by trapping with an electrophile [Si(Me)_3Cl, S_2(Me)_2, and DMF]. Furthermore, 7 was also converted to mono and dicyano derivatives. The anticancer activities of compounds 2, 7, 6, 12, 13, 15, and 16 against HeLa, HT29, and C6 tumor cell lines were tested, and 6,8-dibromo-1,2,3,4-tetrahydroquinoline (2) and 6,8-dimethoxyquinoline (6) showed significant anticancer activities against the tumor cell lines.

Keywords

Anticancer effect, bromoquinoline, cyanoquinoline, lithium--bromine exchange, methoxyquinoline, quinoline derivatives

First Page

896

Last Page

908

Recommended Citation

ÖKTEN, SALİH; ÇAKMAK, OSMAN; ERENLER, RAMAZAN; ŞAHİN, ÖNEM YÜCE; and TEKİN, ŞABAN (2013) "Simple and convenient preparation of novel 6,8-disubstituted quinoline derivatives and their promising anticancer activities," Turkish Journal of Chemistry: Vol. 37: No. 6, Article 5. https://doi.org/10.3906/kim-1301-30
Available at: https://journals.tubitak.gov.tr/chem/vol37/iss6/5