N-functionalized benzimidazol-2-ylidene silver complexes: synthesis, characterization, and antimicrobial studies

Authors

YETKİN GÖK
SENEM AKKOÇ
ÖZLEM ÖZEROĞLU ÇELİKAL
İLKNUR ÖZDEMİR
SELAMİ GÜNAL
ELİF SAYIN

DOI

10.3906/kim-1304-72

Abstract

2-Methoxyethyl, 2-diethylaminoethyl, and 2-phenylethyl-substituted N-heterocyclic carbene (NHC) precursors were treated with Ag_2CO_3 to yield silver(I)-NHC complexes (1a--g) in dichloromethane as a solvent at room temperature. The 7 new silver-NHC complexes were fully characterized by means of ^1H NMR, ^{13}C NMR, and elemental analysis techniques. Using the agar dilution procedure recommended by the Laboratory and Clinical Standards Institute, the antimicrobial activities of all the silver-NHC complexes were studied against 2 gram-negative bacterial strains (Pseudomonas aeruginosa and Escherichia coli), 2 gram-positive bacterial strains (Enterococcus faecalis and Staphylococcus aureus), and 2 fungi (Candida tropicalis and Candida albicans).

Keywords

N-Heterocyclic carbene, benzimidazol-2-ylidene, silver complex, antimicrobial activity, medical inorganic chemistry

First Page

1007

Last Page

1013

Recommended Citation

GÖK, YETKİN; AKKOÇ, SENEM; ÇELİKAL, ÖZLEM ÖZEROĞLU; ÖZDEMİR, İLKNUR; GÜNAL, SELAMİ; and SAYIN, ELİF (2013) "N-functionalized benzimidazol-2-ylidene silver complexes: synthesis, characterization, and antimicrobial studies," Turkish Journal of Chemistry: Vol. 37: No. 6, Article 16. https://doi.org/10.3906/kim-1304-72
Available at: https://journals.tubitak.gov.tr/chem/vol37/iss6/16