Asymmetric Henry reaction catalyzed by Cu(I)-based chiral amino alcohol complex

Authors

TIANHUA SHEN
QUAN QIN
HANG NI
TING XIA
XIAOCONG ZHOU
FUNA CUI
JUNQI LI
DEQIANG RAN
QINGBAO SONG

Abstract

The Cu(I)-based complex prepared from (S)-2-(furan-2-yl-methylamino)-2-phenylethanol (5c) and CuCl was used as catalyst in enantioselective Henry reactions of arylaldehydes and nitromethane, which gave 89% ee and 95% yield at ambient temperature. The proposed catalytic cycle of an asymmetric Henry reaction was suggested.

DOI

10.3906/kim-1210-62

Keywords

Chiral amino alcohol, copper(I) salt, asymmetric catalysis, Henry reaction

First Page

966

Last Page

977

Recommended Citation

SHEN, TIANHUA; QIN, QUAN; NI, HANG; XIA, TING; ZHOU, XIAOCONG; CUI, FUNA; LI, JUNQI; RAN, DEQIANG; and SONG, QINGBAO (2013) "Asymmetric Henry reaction catalyzed by Cu(I)-based chiral amino alcohol complex," Turkish Journal of Chemistry: Vol. 37: No. 6, Article 12. https://doi.org/10.3906/kim-1210-62
Available at: https://journals.tubitak.gov.tr/chem/vol37/iss6/12