Asymmetric Henry reaction catalyzed by Cu(I)-based chiral amino alcohol complex

Authors

TIANHUA SHEN
QUAN QIN
HANG NI
TING XIA
XIAOCONG ZHOU
FUNA CUI
JUNQI LI
DEQIANG RAN
QINGBAO SONG

DOI

10.3906/kim-1210-62

Abstract

The Cu(I)-based complex prepared from (S)-2-(furan-2-yl-methylamino)-2-phenylethanol (5c) and CuCl was used as catalyst in enantioselective Henry reactions of arylaldehydes and nitromethane, which gave 89% ee and 95% yield at ambient temperature. The proposed catalytic cycle of an asymmetric Henry reaction was suggested.

Keywords

Chiral amino alcohol, copper(I) salt, asymmetric catalysis, Henry reaction

First Page

966

Last Page

977

Recommended Citation

SHEN, TIANHUA; QIN, QUAN; NI, HANG; XIA, TING; ZHOU, XIAOCONG; CUI, FUNA; LI, JUNQI; RAN, DEQIANG; and SONG, QINGBAO (2013) "Asymmetric Henry reaction catalyzed by Cu(I)-based chiral amino alcohol complex," Turkish Journal of Chemistry: Vol. 37: No. 6, Article 12. https://doi.org/10.3906/kim-1210-62
Available at: https://journals.tubitak.gov.tr/chem/vol37/iss6/12