Umpolung strategy: advances in catalytic C-C bond formations

Authors

SERKAN EYMUR
MEHMET GÖLLÜ
CİHANGİR TANYELİ

Abstract

This mini-review examines the recent advances in umpolung strategy, devised originally by Corey and Seebach. Although numerous stoichiometric variants have been published to date, this article covers just the catalytic C-C bond forming reactions due to their major benefits such as atom economy, less pollution, and workable simplicity. In the context of umpolung, the studies are evaluated under 3 main titles: enzyme, N-heterocyclic carbene, and cyanide ion catalyzed reactions. In particular, enzyme and NHC catalyzed reactions mainly involve asymmetric applications.

DOI

10.3906/kim-1303-85

Keywords

Umpolung, thiamine pyrophosphate (TPP), N-heterocyclic carbene, asymmetric synthesis

First Page

586

Last Page

609

Recommended Citation

EYMUR, S, GÖLLÜ, M, & TANYELİ, C (2013). Umpolung strategy: advances in catalytic C-C bond formations. Turkish Journal of Chemistry 37 (4): 586-609. https://doi.org/10.3906/kim-1303-85