Umpolung strategy: advances in catalytic C-C bond formations

Authors

SERKAN EYMUR
MEHMET GÖLLÜ
CİHANGİR TANYELİ

DOI

10.3906/kim-1303-85

Abstract

This mini-review examines the recent advances in umpolung strategy, devised originally by Corey and Seebach. Although numerous stoichiometric variants have been published to date, this article covers just the catalytic C-C bond forming reactions due to their major benefits such as atom economy, less pollution, and workable simplicity. In the context of umpolung, the studies are evaluated under 3 main titles: enzyme, N-heterocyclic carbene, and cyanide ion catalyzed reactions. In particular, enzyme and NHC catalyzed reactions mainly involve asymmetric applications.

Keywords

Umpolung, thiamine pyrophosphate (TPP), N-heterocyclic carbene, asymmetric synthesis

First Page

586

Last Page

609

Recommended Citation

EYMUR, SERKAN; GÖLLÜ, MEHMET; and TANYELİ, CİHANGİR (2013) "Umpolung strategy: advances in catalytic C-C bond formations," Turkish Journal of Chemistry: Vol. 37: No. 4, Article 9. https://doi.org/10.3906/kim-1303-85
Available at: https://journals.tubitak.gov.tr/chem/vol37/iss4/9