Anticholinesterase furocoumarins from Heracleum platytaenium, a species endemic to the Ida Mountains

Authors

DEMET DİNCEL
SEDA DAMLA HATIPOĞLU
AHMET CEYHAN GÖREN
GÜLAÇTI TOPÇU

DOI

10.3906/kim-1303-55

Abstract

The petroleum ether extract of Heracleum platytaenium afforded 8 furocoumarins (psoralen, bergapten, xanthotoxin, pimpinellin, isopimpinellin, sphondin, byakangelicin, and heraclenol) and the methanol extract of H. platytaenium gave only 1 glycosylated dihydrofurocoumarin, apterin. In addition, stigmasterol was also obtained from petroleum ether extract. Structure identification of the isolated compounds has been achieved by using spectroscopic methods, namely 1D and 2D NMR experiments and mass spectral analyses. The antioxidant activity of the extracts and pure compounds was investigated by 2 methods, including DPPH free radical scavenging activity and lipid peroxidation inhibitory activity by \beta-carotene-linoleic acid assays. The anticholinesterase activity of petroleum ether and methanol extracts of the plant and the isolated furocoumarins was investigated against acetylcholinesterase and butyrylcholinesterase enzymes by the Ellman method in vitro.

Keywords

Heracleum platytaenium, furocoumarin, antioxidant activity, anticholinesterase activity, pimpinellin, sphondin

First Page

675

Last Page

683

Recommended Citation

DİNCEL, DEMET; HATIPOĞLU, SEDA DAMLA; GÖREN, AHMET CEYHAN; and TOPÇU, GÜLAÇTI (2013) "Anticholinesterase furocoumarins from Heracleum platytaenium, a species endemic to the Ida Mountains," Turkish Journal of Chemistry: Vol. 37: No. 4, Article 14. https://doi.org/10.3906/kim-1303-55
Available at: https://journals.tubitak.gov.tr/chem/vol37/iss4/14