Biotinylated analogs of drug candidates provide useful tools for studying the drug--target protein interactions. Polyhalogenated N,N'diarylureas are potent activators of adenosine monophosphate-activated kinase (AMPK) and potentially promising agents for the treatment of cancer. Various biotinylated versions of these N,N'-diarylureas were synthesized and evaluated in AMPK-activation studies.
SVIRIPA, VITALIY; CONROY, MICHAEL D.; ZHANG, WEN; LIU, ALICE; and WATT, DAVID S.
"Biotinylated N,N'-diarylureas as probes for the activation of adenosine monophosphate-activated kinase (AMPK),"
Turkish Journal of Chemistry: Vol. 37:
4, Article 1.
Available at: https://journals.tubitak.gov.tr/chem/vol37/iss4/1