Biotinylated N,N'-diarylureas as probes for the activation of adenosine monophosphate-activated kinase (AMPK)

Authors

VITALIY SVIRIPA
MICHAEL D. CONROY
WEN ZHANG
ALICE LIU
DAVID S. WATT

Abstract

Biotinylated analogs of drug candidates provide useful tools for studying the drug--target protein interactions. Polyhalogenated N,N'diarylureas are potent activators of adenosine monophosphate-activated kinase (AMPK) and potentially promising agents for the treatment of cancer. Various biotinylated versions of these N,N'-diarylureas were synthesized and evaluated in AMPK-activation studies.

DOI

10.3906/kim-1302-78

Keywords

Adenosine monophosphate-activated kinase, biotinylated N, N'-diarylureas

First Page

473

Last Page

479

Recommended Citation

SVIRIPA, VITALIY; CONROY, MICHAEL D.; ZHANG, WEN; LIU, ALICE; and WATT, DAVID S. (2013) "Biotinylated N,N'-diarylureas as probes for the activation of adenosine monophosphate-activated kinase (AMPK)," Turkish Journal of Chemistry: Vol. 37: No. 4, Article 1. https://doi.org/10.3906/kim-1302-78
Available at: https://journals.tubitak.gov.tr/chem/vol37/iss4/1