Turkish Journal of Chemistry
Abstract
Biotinylated analogs of drug candidates provide useful tools for studying the drug--target protein interactions. Polyhalogenated N,N'diarylureas are potent activators of adenosine monophosphate-activated kinase (AMPK) and potentially promising agents for the treatment of cancer. Various biotinylated versions of these N,N'-diarylureas were synthesized and evaluated in AMPK-activation studies.
DOI
10.3906/kim-1302-78
Keywords
Adenosine monophosphate-activated kinase, biotinylated N, N'-diarylureas
First Page
473
Last Page
479
Recommended Citation
SVIRIPA, V, CONROY, M. D, ZHANG, W, LIU, A, & WATT, D. S (2013). Biotinylated N,N'-diarylureas as probes for the activation of adenosine monophosphate-activated kinase (AMPK). Turkish Journal of Chemistry 37 (4): 473-479. https://doi.org/10.3906/kim-1302-78
