A one-pot strategy for regioselective synthesis of 6-aryl-3-oxo-2,3-dihydropyridazine-4-carbohydrazides

Authors

MEHDI RIMAZ
HOSSEIN MOUSAVI

DOI

10.3906/kim-1210-5

Abstract

A simple and efficient method for the synthesis of 6-aryl-3-oxo-2,3-dihydropyridazine-4-carbohydrazide derivatives was developed. The synthesis was achieved via one-pot multicomponent reaction of arylglyoxals, dialkylmalonates, and hydrazine hydrate in pyridine at room temperature. This procedure features high regioselectivity, generally good to excellent yields, the use of easily available starting materials, and operational simplicity. This chemistry provides an efficient and promising synthetic strategy for diversity-oriented construction of the 6-arylpyridazinone skeleton.

Keywords

Pyridazinone, arylglyoxal, dialkylmalonate, hydrazine, regioselective

First Page

252

Last Page

261

Recommended Citation

RIMAZ, MEHDI and MOUSAVI, HOSSEIN (2013) "A one-pot strategy for regioselective synthesis of 6-aryl-3-oxo-2,3-dihydropyridazine-4-carbohydrazides," Turkish Journal of Chemistry: Vol. 37: No. 2, Article 9. https://doi.org/10.3906/kim-1210-5
Available at: https://journals.tubitak.gov.tr/chem/vol37/iss2/9