Synthesis and evaluation of acetylcholineesterase inhibitory potential and antioxidant activity of benzothiazine derivatives

Authors

DURRE SHAHWAR
UZMA SANA
NAEEM AHMAD

DOI

10.3906/kim-1207-67

Abstract

The aim of the present study was to synthesize and characterize benzothiazine derivatives prepared by using 2-aminothiophenol and saccharine and in vitro screen their enzyme inhibition and antioxidant potential. Nine different derivatives were prepared and their structures were confirmed by spectral studies (EIMS, ^1 H and ^{13}C NMR). Enzyme inhibition potential of the synthesized compounds was evaluated by Ellman's method, while antioxidant activity was determined by DPPH and FRAP assays. All the derivatives showed remarkable activity against acetylcholine esterase with IC_{50} values in the range of 35.9--122.0 \mu M. All other derivatives, except compound 4a, were inactive towards DPPH radical. The results of the FRAP assay showed significant reducing potential of compounds 1, 2, 2a, and 4a.

Keywords

Acetylcholine esterase, benzothiazine, DPPH, FRAP

First Page

262

Last Page

270

Recommended Citation

SHAHWAR, DURRE; SANA, UZMA; and AHMAD, NAEEM (2013) "Synthesis and evaluation of acetylcholineesterase inhibitory potential and antioxidant activity of benzothiazine derivatives," Turkish Journal of Chemistry: Vol. 37: No. 2, Article 10. https://doi.org/10.3906/kim-1207-67
Available at: https://journals.tubitak.gov.tr/chem/vol37/iss2/10