A simple synthetic method is reported for the preparation of some new phosphorus macrocycles in which the pyrazole rings are appended to a phosphorus atom. The methodology is based on the cyclocondensation reaction of bis(4-formylpyrazolyl) phosphine oxide(1a, 1b) with nitrogen nucleophiles that contain active terminal amino groups. The antimicrobial activities of the synthesized compounds were assayed.
ALI, Tarik El-Sayed; ABDEL-GHAFFAR, Salah Abdel-Aziz; EL-MAHDY, Kamilia Mohamed; and ABDEL-KARIM, Somaia Mohamed
"Synthesis, characterization, and antimicrobial activity of some new phosphorus macrocyclic compounds containing pyrazole rings,"
Turkish Journal of Chemistry: Vol. 37:
1, Article 12.
Available at: https://journals.tubitak.gov.tr/chem/vol37/iss1/12