Synthesis and antioxidant and antimicrobial evaluation of novel 4-substituted-1H-1,2,4-triazole derivatives

Authors

SULTAN BAYTAŞ
EVİN KAPÇAK
TÜLAY ÇOBAN
HATİCE ÖZBİLGE

DOI

10.3906/kim-1202-62

Abstract

A series of 4-benzyl/phenyl-3-(1-methyl-1H-indole-2-yl)-1H- 1,2,4-triazole-5(4H)-thione (4a,b) and 2-{4-[benzyl/phenyl-5- (substitutedbenzylthio)]-4H-1,2,4-triazole-3-yl}-1-methyl-1H-indole derivatives (5a-p) were synthesized and evaluated for their in vitro scavenging of DPPH and superoxide radical, and lipid peroxidation inhibition effects as well as their antimicrobial properties. DPPH radical scavenging capacity was found to be equipotent with BHT and found in compounds containing 1,2,4-triazole-5(4H)-thione moiety (4a,b). With regard to antimicrobial properties, compound 5k showed slight antimicrobial activity against all the test microorganisms.

Keywords

Indole, 1, 2, 4-triazole, DPPH, superoxide, lipid peroxidation, antimicrobial activity

First Page

867

Last Page

884

Recommended Citation

BAYTAŞ, SULTAN; KAPÇAK, EVİN; ÇOBAN, TÜLAY; and ÖZBİLGE, HATİCE (2012) "Synthesis and antioxidant and antimicrobial evaluation of novel 4-substituted-1H-1,2,4-triazole derivatives," Turkish Journal of Chemistry: Vol. 36: No. 6, Article 8. https://doi.org/10.3906/kim-1202-62
Available at: https://journals.tubitak.gov.tr/chem/vol36/iss6/8