Synthesis of antipyrine/pyridazinone hybrids and investigation of their in vivo analgesic and anti-inflammatory activities

Authors

SULTAN BAYTAŞ
NAZAN İNCELER
KHATEREH FATTAHPOUR MAVANEH
MECİT ORHAN ULUDAĞ
NURETTİN ABACIOĞLU
MEHTAP GÖKÇE

Abstract

Eleven antipyrine/pyridazinone hybrids were synthesized and evaluated for their in vivo analgesic and anti-inflammatory activities by p-benzoquinone-induced writhing test and carrageenan-induced paw edema model, respectively. The test results indicated that compounds 6a, 6c, and 6d were equally or more potent analgesic and anti-inflammatory agents than aspirin and indomethacin, respectively. Side effects of the compounds were examined on gastric mucosa. Most of the compounds were found to be non-ulcerogenic under test conditions.

DOI

10.3906/kim-1111-29

Keywords

Hybrid, antipyrine, pyridazinone, writhing, carrageenan

First Page

734

Last Page

748

Recommended Citation

BAYTAŞ, S, İNCELER, N, MAVANEH, K. F, ULUDAĞ, M. O, ABACIOĞLU, N, & GÖKÇE, M (2012). Synthesis of antipyrine/pyridazinone hybrids and investigation of their in vivo analgesic and anti-inflammatory activities. Turkish Journal of Chemistry 36 (5): 734-748. https://doi.org/10.3906/kim-1111-29