Synthesis and antimicrobial activity of some novel 4-hydroxyquinolin-2(1H)-ones and pyrano[3,2-c] quinolinones from 3-(1-ethy1-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)-3-oxopropanoic acid

Authors

HANY MOHAMED HASSANIN
MAGDY AHMED IBRAHIM
YOUSSEF ABDEL-SALAM ALNAMER

DOI

10.3906/kim-1111-14

Abstract

Chlorination, bromination, and condensation reactions of 3-(1-ethy1-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)-3-oxopropanoic acid (3) were studied. Some novel 4-hydroxyquinolin-2(1H)-ones and pyrano[3,2-c]quinolin-2(1H)-ones were also prepared. The structures of the novel compounds were established by elemental analyses and spectral data. All the products were also screened in vitro for their antimicrobial activity.

Keywords

\beta-Ketoacid, 4-hydroxyquinolin-2(1H)-one, pyrano[3, 2-c]quinolinone, condensation reactions

First Page

682

Last Page

699

Recommended Citation

HASSANIN, HANY MOHAMED; IBRAHIM, MAGDY AHMED; and ALNAMER, YOUSSEF ABDEL-SALAM (2012) "Synthesis and antimicrobial activity of some novel 4-hydroxyquinolin-2(1H)-ones and pyrano[3,2-c] quinolinones from 3-(1-ethy1-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)-3-oxopropanoic acid," Turkish Journal of Chemistry: Vol. 36: No. 5, Article 4. https://doi.org/10.3906/kim-1111-14
Available at: https://journals.tubitak.gov.tr/chem/vol36/iss5/4