Reactions of N-isocyaniminotriphenylphosphorane with 2-oxopropyl benzoate (or 2-oxopropyl 4-bromobenzoate) in the presence of 3-phenyl-2-propynoic acid and primary amines proceeded smoothly at room temperature and in neutral conditions to afford sterically congested 1,3,4-oxadiazole derivatives in high yields. The reaction proceeded smoothly and cleanly under mild conditions and no side reactions were observed.
2-Oxopropyl benzoate, 2-oxopropyl 4-bromobenzoate, 3-phenyl-2-propynoic acid, 1, 3, 4-oxadiazole, N-isocyaniminotriphenylphosphorane
HOLAGH, MOHSEN VALIZADEH; MAHARRAMOV, ABEL MOHAMMADALI OGLU; ALLAHVERDIYEV, MIRZA ALIAKBAR OGLU; RAMAZANI, ALI; AHMADI, YAVAR; NASRABADI, FATEMEH ZEINALI; and SOULDOZI, ALI
"A one-pot efficient four-component reaction for the synthesis of 2-(arylamino)-2-(5-aryl-1-ethenyl-1,3,4-oxadiazol-2-yl)propyl benzoate (or 4-bromobenzoate) derivatives,"
Turkish Journal of Chemistry: Vol. 36:
5, Article 3.
Available at: https://journals.tubitak.gov.tr/chem/vol36/iss5/3