A one-pot efficient four-component reaction for the synthesis of 2-(arylamino)-2-(5-aryl-1-ethenyl-1,3,4-oxadiazol-2-yl)propyl benzoate (or 4-bromobenzoate) derivatives

Authors

MOHSEN VALIZADEH HOLAGH
ABEL MOHAMMADALI OGLU MAHARRAMOV
MIRZA ALIAKBAR OGLU ALLAHVERDIYEV
ALI RAMAZANI
YAVAR AHMADI
FATEMEH ZEINALI NASRABADI
ALI SOULDOZI

Abstract

Reactions of N-isocyaniminotriphenylphosphorane with 2-oxopropyl benzoate (or 2-oxopropyl 4-bromobenzoate) in the presence of 3-phenyl-2-propynoic acid and primary amines proceeded smoothly at room temperature and in neutral conditions to afford sterically congested 1,3,4-oxadiazole derivatives in high yields. The reaction proceeded smoothly and cleanly under mild conditions and no side reactions were observed.

DOI

10.3906/kim-1111-45

Keywords

2-Oxopropyl benzoate, 2-oxopropyl 4-bromobenzoate, 3-phenyl-2-propynoic acid, 1, 3, 4-oxadiazole, N-isocyaniminotriphenylphosphorane

First Page

671

Last Page

681

Recommended Citation

HOLAGH, M. V, MAHARRAMOV, A. M, ALLAHVERDIYEV, M. A, RAMAZANI, A, AHMADI, Y, NASRABADI, F. Z, & SOULDOZI, A (2012). A one-pot efficient four-component reaction for the synthesis of 2-(arylamino)-2-(5-aryl-1-ethenyl-1,3,4-oxadiazol-2-yl)propyl benzoate (or 4-bromobenzoate) derivatives. Turkish Journal of Chemistry 36 (5): 671-681. https://doi.org/10.3906/kim-1111-45