Determination of lidocaine based on electrocatalysis of a chemically modified electrode

Authors

GAMZE TAN
GÜLÇİN BOLAT
MEHMET ALİ ONUR
SERDAR ABACI

Abstract

The potential application of biochemically modified electrodes was investigated for construction of a drug biosensor. The electrocatalytic response of lidocaine was examined through modified electrodes using the electron transfer ability of hemoglobin (Hb) immobilized on gold film modified with a self-assembled monolayer (SAM) of 3-mercaptopropionic acid (MPA). According to the results of voltammetric studies, Au/MPA/Hb electrodes exhibited high sensitivity and good electrocatalytic activity for the reduction of lidocaine, motivating us to construct drug biosensors. With this study, a new electroanalytical procedure is proposed for the determination of lidocaine level in medical applications or therapeutic formulations containing lidocaine as the active ingredient.

DOI

10.3906/kim-1112-6

Keywords

Lidocaine, hemoglobin, chemically modified electrodes, drug biosensor, electrochemistry

First Page

593

Last Page

600

Recommended Citation

TAN, GAMZE; BOLAT, GÜLÇİN; ONUR, MEHMET ALİ; and ABACI, SERDAR (2012) "Determination of lidocaine based on electrocatalysis of a chemically modified electrode," Turkish Journal of Chemistry: Vol. 36: No. 4, Article 10. https://doi.org/10.3906/kim-1112-6
Available at: https://journals.tubitak.gov.tr/chem/vol36/iss4/10