Turkish Journal of Chemistry
Abstract
The potential application of biochemically modified electrodes was investigated for construction of a drug biosensor. The electrocatalytic response of lidocaine was examined through modified electrodes using the electron transfer ability of hemoglobin (Hb) immobilized on gold film modified with a self-assembled monolayer (SAM) of 3-mercaptopropionic acid (MPA). According to the results of voltammetric studies, Au/MPA/Hb electrodes exhibited high sensitivity and good electrocatalytic activity for the reduction of lidocaine, motivating us to construct drug biosensors. With this study, a new electroanalytical procedure is proposed for the determination of lidocaine level in medical applications or therapeutic formulations containing lidocaine as the active ingredient.
DOI
10.3906/kim-1112-6
Keywords
Lidocaine, hemoglobin, chemically modified electrodes, drug biosensor, electrochemistry
First Page
593
Last Page
600
Recommended Citation
TAN, G, BOLAT, G, ONUR, M. A, & ABACI, S (2012). Determination of lidocaine based on electrocatalysis of a chemically modified electrode. Turkish Journal of Chemistry 36 (4): 593-600. https://doi.org/10.3906/kim-1112-6
