Determination of lidocaine based on electrocatalysis of a chemically modified electrode

Authors

GAMZE TAN
GÜLÇİN BOLAT
MEHMET ALİ ONUR
SERDAR ABACI

DOI

10.3906/kim-1112-6

Abstract

The potential application of biochemically modified electrodes was investigated for construction of a drug biosensor. The electrocatalytic response of lidocaine was examined through modified electrodes using the electron transfer ability of hemoglobin (Hb) immobilized on gold film modified with a self-assembled monolayer (SAM) of 3-mercaptopropionic acid (MPA). According to the results of voltammetric studies, Au/MPA/Hb electrodes exhibited high sensitivity and good electrocatalytic activity for the reduction of lidocaine, motivating us to construct drug biosensors. With this study, a new electroanalytical procedure is proposed for the determination of lidocaine level in medical applications or therapeutic formulations containing lidocaine as the active ingredient.

Keywords

Lidocaine, hemoglobin, chemically modified electrodes, drug biosensor, electrochemistry

First Page

593

Last Page

600

Recommended Citation

TAN, GAMZE; BOLAT, GÜLÇİN; ONUR, MEHMET ALİ; and ABACI, SERDAR (2012) "Determination of lidocaine based on electrocatalysis of a chemically modified electrode," Turkish Journal of Chemistry: Vol. 36: No. 4, Article 10. https://doi.org/10.3906/kim-1112-6
Available at: https://journals.tubitak.gov.tr/chem/vol36/iss4/10