Synthesis, characterization, and antioxidant activities of new trisubstituted triazoles

Authors

KEMAL SANCAK
YASEMİN ÜNVER
DİLEK ÜNLÜER
ESRA DÜĞDÜ
GÜLCAN KÖR
FATİH ÇELİK
EMRAH BİRİNCİ

DOI

10.3906/kim-1110-43

Abstract

A series of new 4-(3,4dimethoxyphenethyl)-3,5-akyl/aryl-4H- 1,2,4-triazoles (3a-g) were obtained by reaction of ethyl N'-(alkylidene/arylidene)hydrazonate (1) and 2-(3,4-dimethoxy phenyl)ethanamine (2). Compounds 4d, e, and g were synthesized from the reaction of corresponding compounds 3d, e, and g with BBr_3, respectively. The 10 new compounds synthesized were characterized by elemental analyses, IR, ^1H-NMR, and ^{13}C-NMR spectral data. The structure of compound 3g was inferred through IR, ^1H-, ^{13}C-NMR, elemental analyses, and X-ray spectral techniques. In addition, the newly synthesized chemicals were screened for their antioxidant properties. Among the chemicals tested, 4d, e, and g exhibited the highest degree of antioxidant activity.

Keywords

Synthesis, 1, 2, 4-triazole, antioxidant activity, boron tribromide, X-ray

First Page

457

Last Page

466

Recommended Citation

SANCAK, KEMAL; ÜNVER, YASEMİN; ÜNLÜER, DİLEK; DÜĞDÜ, ESRA; KÖR, GÜLCAN; ÇELİK, FATİH; and BİRİNCİ, EMRAH (2012) "Synthesis, characterization, and antioxidant activities of new trisubstituted triazoles," Turkish Journal of Chemistry: Vol. 36: No. 3, Article 9. https://doi.org/10.3906/kim-1110-43
Available at: https://journals.tubitak.gov.tr/chem/vol36/iss3/9