Turkish Journal of Chemistry
Abstract
Reaction of an isocyanide with an iminium ion intermediate, formed by reaction between 2-oxo-2-phenylacetaldehyde and a secondary amine in the presence of silica nanoparticles, proceeds smoothly at room temperature to afford ketoamide derivatives in high yields.
DOI
10.3906/kim-1111-1
Keywords
Silica nanoparticles, multicomponent reaction, isocyanide, 2-oxo-2-phenylacetaldehyde, secondary amine, iminium ion
First Page
467
Last Page
476
Recommended Citation
RAMAZANI, A, DASTANRA, K, NASRABADI, F. Z, KARIMI, Z, ROUHANI, M, & HOSSEINI, M (2012). Silica nanoparticles as a high efficient catalyst for the one-pot synthesis of 3-oxo-3-phenylpropanamid derivatives from isocyanides, phenylacetaldehyde and secondary amines. Turkish Journal of Chemistry 36 (3): 467-476. https://doi.org/10.3906/kim-1111-1