Silica nanoparticles as a high efficient catalyst for the one-pot synthesis of 3-oxo-3-phenylpropanamid derivatives from isocyanides, phenylacetaldehyde and secondary amines

Authors

ALI RAMAZANI
KOUROSH DASTANRA
FATEMEH ZEINALI NASRABADI
ZAHRA KARIMI
MORTEZA ROUHANI
MEHDI HOSSEINI

Abstract

Reaction of an isocyanide with an iminium ion intermediate, formed by reaction between 2-oxo-2-phenylacetaldehyde and a secondary amine in the presence of silica nanoparticles, proceeds smoothly at room temperature to afford ketoamide derivatives in high yields.

DOI

10.3906/kim-1111-1

Keywords

Silica nanoparticles, multicomponent reaction, isocyanide, 2-oxo-2-phenylacetaldehyde, secondary amine, iminium ion

First Page

467

Last Page

476

Recommended Citation

RAMAZANI, A, DASTANRA, K, NASRABADI, F. Z, KARIMI, Z, ROUHANI, M, & HOSSEINI, M (2012). Silica nanoparticles as a high efficient catalyst for the one-pot synthesis of 3-oxo-3-phenylpropanamid derivatives from isocyanides, phenylacetaldehyde and secondary amines. Turkish Journal of Chemistry 36 (3): 467-476. https://doi.org/10.3906/kim-1111-1