Reaction of an isocyanide with an iminium ion intermediate, formed by reaction between 2-oxo-2-phenylacetaldehyde and a secondary amine in the presence of silica nanoparticles, proceeds smoothly at room temperature to afford ketoamide derivatives in high yields.
RAMAZANI, ALI; DASTANRA, KOUROSH; NASRABADI, FATEMEH ZEINALI; KARIMI, ZAHRA; ROUHANI, MORTEZA; and HOSSEINI, MEHDI
"Silica nanoparticles as a high efficient catalyst for the one-pot synthesis of 3-oxo-3-phenylpropanamid derivatives from isocyanides, phenylacetaldehyde and secondary amines,"
Turkish Journal of Chemistry: Vol. 36:
3, Article 10.
Available at: https://journals.tubitak.gov.tr/chem/vol36/iss3/10