Silica nanoparticles as a high efficient catalyst for the one-pot synthesis of 3-oxo-3-phenylpropanamid derivatives from isocyanides, phenylacetaldehyde and secondary amines

Authors

ALI RAMAZANI
KOUROSH DASTANRA
FATEMEH ZEINALI NASRABADI
ZAHRA KARIMI
MORTEZA ROUHANI
MEHDI HOSSEINI

DOI

10.3906/kim-1111-1

Abstract

Reaction of an isocyanide with an iminium ion intermediate, formed by reaction between 2-oxo-2-phenylacetaldehyde and a secondary amine in the presence of silica nanoparticles, proceeds smoothly at room temperature to afford ketoamide derivatives in high yields.

Keywords

Silica nanoparticles, multicomponent reaction, isocyanide, 2-oxo-2-phenylacetaldehyde, secondary amine, iminium ion

First Page

467

Last Page

476

Recommended Citation

RAMAZANI, ALI; DASTANRA, KOUROSH; NASRABADI, FATEMEH ZEINALI; KARIMI, ZAHRA; ROUHANI, MORTEZA; and HOSSEINI, MEHDI (2012) "Silica nanoparticles as a high efficient catalyst for the one-pot synthesis of 3-oxo-3-phenylpropanamid derivatives from isocyanides, phenylacetaldehyde and secondary amines," Turkish Journal of Chemistry: Vol. 36: No. 3, Article 10. https://doi.org/10.3906/kim-1111-1
Available at: https://journals.tubitak.gov.tr/chem/vol36/iss3/10