Turkish Journal of Chemistry
Abstract
A highly efficient and versatile synthetic approach to the synthesis of annelated phthalazine derivatives viz. 1,2,4-triazolo [3,4-a]phthalazine 11a,b, 14, 18, 19a,b, 29-31, 33, 1,2,4-triazino [3,4-a]phthalazine 25a,b-28, 1,3,5-triazino[4,3-a]phthalazine 22, tetrazolo[5,1-a] phthalazine 23, imidazophthalazine 9a,b,15, and pyrimidinophthlazine 6, 10, 16, 17, 20 is presented. Moreover, acyclo C-nucleoside and double headed acyclo C-nucleoside of 1,2,4-triazolo[3,4-a]phthalazine 12, 13 were obtained via heterocyclization reaction of 1-chloro-4-(2,4,6-trimethylphenyl) phthalazine (4) with gluconic acid hydrazide and galactaric acid bis hydrazide, respectively. The new compounds were synthesized with the objective of studying their antimicrobial activity.
DOI
10.3906/kim-1111-52
Keywords
Triazinophthalazine, pyrazolylphthalazine, triazolophthalazine, antimicrobial activity
First Page
347
Last Page
366
Recommended Citation
El-Hashash, Maher Abdel Aziz; Soliman, Ahmed Youssef; and ELSHAMY, Ibrahim Essam
(2012)
"Synthesis and antimicrobial evaluation of some annelated phthalazine derivatives and acyclo C-nucleosides from 1-chloro-4-(2,4,6-trimethylphenyl) phthalazine precursor,"
Turkish Journal of Chemistry: Vol. 36:
No.
3, Article 1.
https://doi.org/10.3906/kim-1111-52
Available at:
https://journals.tubitak.gov.tr/chem/vol36/iss3/1